The heterogeneity and clonal evolution analysis of the advanced prostate cancer with castration resistance.

ABSTRACT:

Background

Nowadays, the incidence rate of advanced and metastatic prostate cancer at the first time of diagnosis grows higher in China yearly. At present, androgen deprivation therapy (ADT) is the primary treatment of advanced prostate cancer. However, after several years of ADT, most patients will ultimately progress to castration-resistant prostate cancer (CRPC). Previous studies mainly focus on Caucasian and very few on East Asian patients.

Methods

In this study, the pre- and post-ADT tumor samples were collected from five Chinese patients with advanced prostate cancer. The whole-exome sequencing, tumor heterogeneity, and clonal evolution pattern were analyzed.

Results

The results showed that the gene mutation pattern and heterogeneity changed significantly after

SUBMITTER: Liu A 

PROVIDER: S-EPMC10510184 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature