Effect of genetic liability to migraine and its subtypes on breast cancer: a mendelian randomization study.

ABSTRACT:

Background

The relationship between migraine and breast cancer risk has generated conflicting findings. We attempted to assess the association between migraine and breast cancer risk using Mendelian randomization (MR) analysis.

Methods

We selected genetic instruments associated with migraine from a recently published genome-wide association studies (GWAS). Inverse variant weighted (IVW) analysis was adopted as the main method, and we also performed the weighted-median method and the MR‒Egger, MR pleiotropy residual sum and outlier (MR-PRESSO), and MR Robust Adjusted Profile Score (MR-RAPS) methods as supplements.

Results

Our MR suggested that any migraine (AM) was a risk factor for overall breast cancer (IVW: odds ratio (OR) = 1.072, 95% confidence intervals (CI) = 1.

SUBMITTER: Fang T 

PROVIDER: S-EPMC10510189 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature