Neuron-derived extracellular vesicles in blood reveal effects of exercise in Alzheimer's disease.

ABSTRACT:

Background

Neuron-derived extracellular vesicles (NDEVs) in blood may be used to derive biomarkers for the effects of exercise in Alzheimer's disease (AD). For this purpose, we studied changes in neuroprotective proteins proBDNF, BDNF, and humanin in plasma NDEVs from patients with mild to moderate AD participating in the randomized controlled trial (RCT) of exercise ADEX.

Methods

proBDNF, BDNF, and humanin were quantified in NDEVs immunocaptured from the plasma of 95 ADEX participants, randomized into exercise and control groups, and collected at baseline and 16 weeks. Exploratorily, we also quantified NDEV levels of putative exerkines known to respond to exercise in peripheral tissues.

Results

NDEV levels of proBDNF, BDNF, and humanin increased in the exercise group

SUBMITTER: Delgado-Peraza F 

PROVIDER: S-EPMC10510190 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature