Inhibitory effect of O-propargyllawsone in A549 lung adenocarcinoma cells.

ABSTRACT:

Background

Lung cancer is the deadliest type of cancer in the world and the search for compounds that can treat this disease is highly important. Lawsone (2-hydroxy-1,4-naphtoquinone) is a naphthoquinone found in plants from the Lawsone genus that show a high cytotoxic effect in cancer cell lines and its derivatives show an even higher cytotoxic effect.

Methods

Sulforhodamine B was used to evaluate the cytotoxic activity of compounds on tumor cells. Clonogenic assay was used to analyze the reduction of colonies and wound healing assay to the migratory capacity of A549 cells. Apoptosis and necrosis were analyzed by flow cytometer and Giemsa staining. Hemolysis assay to determine toxicity in human erythrocytes.

Results

Lawsone derivatives were evaluated and compound 1 (

SUBMITTER: Dos Santos EWP 

PROVIDER: S-EPMC10510246 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature