KDM2B regulates inflammation and oxidative stress of sepsis via targeting NF-κB and AP-1 pathways.

ABSTRACT:

Backgrounds

The kidney is an easily affected organ with sepsis which is a main underlying cause of acute kidney injury (AKI). Histone-modifying lysine-specific demethylase 2B (KDM2B) is involved in numerous pathological processes, such as cell senescence and tumor development. However, the role of KDM2B in sepsis-induced AKI is unclear.

Objects

To investigate the role of KDM2B on cell viability, inflammation and oxidative stress of sepsis-associated AKI, and the involved signaling pathways.

Methods

An AKI model in vitro was established through lipopolysaccharide (LPS)-induction in HK-2 cells. Western blots were performed to evaluate the expression of KDM2B, cyclooxygenase 2 (COX2), inducible nitric oxide synthase (iNOS), p65, c-Jun and c-Fos, as well as p65 phosphoryl

SUBMITTER: Li X 

PROVIDER: S-EPMC10510463 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature