Exploitation of Engineered Light-Switchable Myosin XI for Nanotechnological Applications.

ABSTRACT: For certain nanotechnological applications of the contractile proteins actin and myosin, e.g., in biosensing and network-based biocomputation, it would be desirable to temporarily switch on/off motile function in parts of nanostructured devices, e.g., for sorting or programming. Myosin XI motor constructs, engineered with a light-switchable domain for switching actin motility between high and low velocities (light-sensitive motors (LSMs) below), are promising in this regard. However, they were not designed for use in nanotechnology, where longevity of operation, long shelf life, and selectivity of function in specific regions of a nanofabricated network are important. Here, we tested if these criteria can be fulfilled using existing LSM constructs or if additional development

SUBMITTER: Salhotra A 

PROVIDER: S-EPMC10510702 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature