Amyloid Fibrils Formed by Short Prion-Inspired Peptides Are Metalloenzymes.

ABSTRACT: Enzymes typically fold into defined 3D protein structures exhibiting a high catalytic efficiency and selectivity. It has been proposed that the earliest enzymes may have arisen from the self-assembly of short peptides into supramolecular amyloid-like structures. Several artificial amyloids have been shown to display catalytic activity while offering advantages over natural enzymes in terms of modularity, flexibility, stability, and reusability. Hydrolases, especially esterases, are the most common artificial amyloid-like nanozymes with some reported to act as carbonic anhydrases (CA). Their hydrolytic activity is often dependent on the binding of metallic cofactors through a coordination triad composed of His residues in the β-strands, which mimic the arrangement found in natural metalloen

SUBMITTER: Navarro S 

PROVIDER: S-EPMC10510724 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature