FreeFlux: A Python Package for Time-Efficient Isotopically Nonstationary Metabolic Flux Analysis.

ABSTRACT: ¹³C metabolic flux analysis is a powerful tool for metabolism characterization in metabolic engineering and synthetic biology. However, the widespread adoption of this tool is hindered by limited software availability and computational efficiency. Currently, the most widely accepted ¹³C-flux tools, such as INCA and 13CFLUX2, are developed in a closed-source environment. While several open-source packages or software are available, they are either computationally inefficient or only suitable for flux estimation at isotopic steady state. To address the need for a time-efficient computational tool for the more complicated flux analysis at an isotopically nonstationary state, especially for understanding the single-carbon substrate metabolism, we present FreeFlux. FreeFlu

SUBMITTER: Wu C 

PROVIDER: S-EPMC10510750 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature