Vascular Response to Spreading Depolarization Predicts Stroke Outcome.

ABSTRACT:

Background

Cortical spreading depolarization (CSD) is a massive neuro-glial depolarization wave, which propagates across the cerebral cortex. In stroke, CSD is a necessary and ubiquitous mechanism for the development of neuronal lesions that initiates in the ischemic core and propagates through the penumbra extending the tissue injury. Although CSD propagation induces dramatic changes in cerebral blood flow, the vascular responses in different ischemic regions and their consequences on reperfusion and recovery remain to be defined.

Methods

Ischemia was performed using the thrombin model of stroke and reperfusion was induced by r-tPA (recombinant tissue-type plasminogen activator) administration in mice. We used in vivo electrophysiology and laser speckle contrast imaging sim

SUBMITTER: Binder NF 

PROVIDER: S-EPMC10510800 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature