Temporal Trends and Lesion Sets for Persistent Atrial Fibrillation Ablation: A Meta-Analysis With Trial Sequential Analysis and Meta-Regression.

ABSTRACT:

Background

Ablation for persistent atrial fibrillation (PsAF) has been performed for over 20 years, although success rates have remained modest. Several adjunctive lesion sets have been studied but none have become standard of practice. We sought to describe how the efficacy of ablation for PsAF has evolved in this time period with a focus on the effect of adjunctive ablation strategies.

Methods

Databases were searched for prospective studies of PsAF ablation. We performed meta-regression and trial sequential analysis.

Results

A total of 99 studies (15 424 patients) were included. Ablation for PsAF achieved the primary outcome (freedom of atrial fibrillation/atrial tachycardia rate at 12 months follow-up) in 48.2% (5% CI, 44.0-52.3). Meta-regression showed freedom fro

SUBMITTER: Sau A 

PROVIDER: S-EPMC10510845 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature