Plasma type I collagen α1 chain in relation to coronary artery disease: findings from a prospective population-based cohort and an acute myocardial infarction prospective cohort in Sweden.

ABSTRACT:

Objectives

To investigate the association between type I collagen α1 chain (COL1α1) levels and coronary artery disease (CAD) by using absolute quantification in plasma. Also, to investigate the correlates of COL1α1 to clinical characteristics and circulating markers of collagen metabolism.

Design

Life conditions, Stress and Health (LSH) study: prospective cohort study, here with a nested case-control design.Assessing Platelet Activity in Coronary Heart Disease (APACHE) study: prospective cohort study.

Setting

LSH: primary care setting, southeast Sweden.APACHE: cardiology department, university hospital, southeast Sweden.

Participants

LSH: 1007 randomly recruited individuals aged 45-69 (50% women). Exclusion criteria was serious disease. After 13 years of follow

SUBMITTER: Hammareus F 

PROVIDER: S-EPMC10510861 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature