Appropriate tension sensitivity of α-catenin ensures rounding morphogenesis of epithelial spheroids.

ABSTRACT: The adherens junction (AJ) is an actin filament-anchoring junction. It plays a central role in epithelial morphogenesis through cadherin-based recognition and adhesion among cells. The stability and plasticity of AJs are required for the morphogenesis. An actin-binding α-catenin is an essential component of the cadherin-catenin complex and functions as a tension transducer that changes its conformation and induces AJ development in response to tension. Despite much progress in understanding molecular mechanisms of tension sensitivity of α-catenin, its significance on epithelial morphogenesis is still unknown. Here we show that the tension sensitivity of α-catenin is essential for epithelial cells to form round spheroids through proper multicellular rearrangement. Using a novel in vitro sus

SUBMITTER: Nishimura R 

PROVIDER: S-EPMC10511042 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature