Peri-operative pharmacokinetics of cefazolin prophylaxis during valve replacement surgery.

ABSTRACT:

Objective

There is little prospective data to guide effective dosing for antibiotic prophylaxis during surgery requiring cardiopulmonary bypass (CPB). We aim to describe the effects of CPB on the population pharmacokinetics (PK) of total and unbound concentrations of cefazolin and to recommend optimised dosing regimens.

Methods

Patients undergoing CPB for elective cardiac valve replacement were included using convenience sampling. Intravenous cefazolin (2g) was administered pre-incision and re-dosed at 4 hours. Serial blood and urine samples were collected and analysed using validated chromatography. Population PK modelling and Monte-Carlo simulations were performed using Pmetrics® to determine the fractional target attainment (FTA) of achieving unbound concentrations exceed

SUBMITTER: Alli A 

PROVIDER: S-EPMC10511078 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature