Inositol pyrophosphate dynamics reveals control of the yeast phosphate starvation program through 1,5-IP₈ and the SPX domain of Pho81.

ABSTRACT: Eukaryotic cells control inorganic phosphate to balance its role as essential macronutrient with its negative bioenergetic impact on reactions liberating phosphate. Phosphate homeostasis depends on the conserved INPHORS signaling pathway that utilizes inositol pyrophosphates and SPX receptor domains. Since cells synthesize various inositol pyrophosphates and SPX domains bind them promiscuously, it is unclear whether a specific inositol pyrophosphate regulates SPX domains in vivo, or whether multiple inositol pyrophosphates act as a pool. In contrast to previous models, which postulated that phosphate starvation is signaled by increased production of the inositol pyrophosphate 1-IP₇, we now show that the levels of all detectable inositol pyrophosphates of yeast, 1-IP₇,

SUBMITTER: Chabert V 

PROVIDER: S-EPMC10511240 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature