Distinct B cell profiles characterise healthy weight and obesity pre- and post-bariatric surgery.

ABSTRACT:

Background/objectives

Obesity-associated metabolic dysfunction and inflammation can be ameliorated by bariatric surgery. While obesity is also linked to impaired B cell activation, differentiation, and persistence in response to infection and vaccination little is known about post-operative immune B cell compartment and to what extent dysregulation in B cell pathways can be reversed. To bridge this gap in knowledge, we carried out in-depth evaluation of B cell composition in individuals with obesity prior to and following bariatric surgery compared to lean controls.

Subjects/methods

We recruited individuals with obesity (BMI at least 35 kg/m²) before bariatric surgery (n = 21) and followed them up 6 months post-operatively (n = 17). As controls we recruited age- a

SUBMITTER: Slisere B 

PROVIDER: S-EPMC10511309 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature