Dopamine and glutamate regulate striatal acetylcholine in decision-making.

ABSTRACT: Striatal dopamine and acetylcholine are essential for the selection and reinforcement of motor actions and decision-making¹. In vitro studies have revealed an intrastriatal circuit in which acetylcholine, released by cholinergic interneurons (CINs), drives the release of dopamine, and dopamine, in turn, inhibits the activity of CINs through dopamine D2 receptors (D2Rs). Whether and how this circuit contributes to striatal function in vivo is largely unknown. Here, to define the role of this circuit in a living system, we monitored acetylcholine and dopamine signals in the ventrolateral striatum of mice performing a reward-based decision-making task. We establish that dopamine and acetylcholine exhibit multiphasic and anticorrelated transients that are modulated by decision histo

SUBMITTER: Chantranupong L 

PROVIDER: S-EPMC10511323 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature