Stability of human gut microbiome: Comparison of ecological modelling and observational approaches.

ABSTRACT: The gut microbiome plays a pivotal role in the human body, and perturbations in its composition have been linked to various disorders. Stability is an essential property of a healthy human gut microbiome, which allows it to maintain its functional richness under the external influences. This property has been explored through two distinct methodologies - mathematical modelling based on ecological principles and statistical analysis drawn from observations in interventional studies. Here we conducted a meta-analysis aimed to compare the two approaches utilising the data from 9 interventional and time series studies encompassing 3512 gut microbiome profiles obtained via 16S rRNA gene sequencing. By employing the previously published compositional Lotka-Volterra method, we modelled the dynami

SUBMITTER: Revel-Muroz A 

PROVIDER: S-EPMC10511340 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature