An intracellular isotropic diffusion signal is positively associated with pubertal development in white matter.

ABSTRACT: Puberty is a key event in adolescent development that involves significant, hormone-driven changes to many aspects of physiology including the brain. Understanding how the brain responds during this time period is important for evaluating neuronal developments that affect mental health throughout adolescence and the adult lifespan. This study examines diffusion MRI scans from the cross-sectional ABCD Study baseline cohort, a large multi-site study containing thousands of participants, to describe the relationship between pubertal development and brain microstructure. Using advanced, 3-tissue constrained spherical deconvolution methods, this study is able to describe multiple tissue compartments beyond only white matter (WM) axonal qualities. After controlling for age, sex, brain volume, su

SUBMITTER: Newman BT 

PROVIDER: S-EPMC10511341 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature