Colocalization of expression transcripts with COVID-19 outcomes is rare across cell states, cell types and organs.

ABSTRACT: Identifying causal genes at GWAS loci can help pinpoint targets for therapeutic interventions. Expression studies can disentangle such loci but signals from expression quantitative trait loci (eQTLs) often fail to colocalize-which means that the genetic control of measured expression is not shared with the genetic control of disease risk. This may be because gene expression is measured in the wrong cell type, physiological state, or organ. We tested whether Mendelian randomization (MR) could identify genes at loci influencing COVID-19 outcomes and whether the colocalization of genetic control of expression and COVID-19 outcomes was influenced by cell type, cell stimulation, and organ. We conducted MR of cis-eQTLs from single cell (scRNA-seq) and bulk RNA sequencing. We then tested variable

SUBMITTER: Willett JDS 

PROVIDER: S-EPMC10511363 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature