The effects of resuscitation with different plasma products on endothelial permeability and organ injury in a rat pneumosepsis model.

ABSTRACT:

Background

Endothelial injury and permeability are a hallmark of sepsis. Initial resuscitation of septic patients with crystalloids is associated with aggravation of endothelial permeability, which may be related either to low protein content or to volume. We investigated whether initial resuscitation with different types of plasma or albumin decreases endothelial dysfunction and organ injury in a pneumosepsis rat model compared to the same volume of crystalloids.

Study design and methods

Sprague-Dawley rats were intratracheally inoculated with Streptococcus pneumoniae. Twenty-four hours after inoculation, animals were randomized to 2 control groups and 5 intervention groups (n = 11 per group) to receive resuscitation with a fixed volume (8 mL/kg for 1 h) of either Ringer's

SUBMITTER: van den Brink DP 

PROVIDER: S-EPMC10511387 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature