Biomechanical characterization of tissue types in murine dissecting aneurysms based on histology and 4D ultrasound-derived strain.

ABSTRACT: Abdominal aortic aneurysm disease is the local enlargement of the aorta, typically in the infrarenal section, causing up to 200,000 deaths/year. In vivo information to characterize the individual elastic properties of the aneurysm wall in terms of rupture risk is lacking. We used a method that combines 4D ultrasound and direct deformation estimation to compute in vivo 3D Green-Lagrange strain in murine angiotensin II-induced dissecting aortic aneurysms, a commonly used mouse model. After euthanasia, histological staining of cross-sectional sections along the aorta was performed in areas where in vivo strains had previously been measured. The histological sections were segmented into intact and fragmented elastin, thrombus with and without red blood cells, and outer vessel wall including th

SUBMITTER: Hegner A 

PROVIDER: S-EPMC10511389 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature