Leptin receptor gene deficiency minimally affects osseointegration in rats.

ABSTRACT: Metabolic syndrome represents a cluster of conditions such as obesity, hyperglycaemia, dyslipidaemia, and hypertension that can lead to type 2 diabetes mellitus and/or cardiovascular disease. Here, we investigated the influence of obesity and hyperglycaemia on osseointegration using a novel, leptin receptor-deficient animal model, the Lund MetS rat. Machined titanium implants were installed in the tibias of animals with normal leptin receptor (LepR^+/+) and those harbouring congenic leptin receptor deficiency (LepR^-/-) and were left to heal for 28 days. Extensive evaluation of osseointegration was performed using removal torque measurements, X-ray micro-computed tomography, quantitative backscattered electron imaging, Raman spectroscopy, gene expression analysis, quali

SUBMITTER: Jolic M 

PROVIDER: S-EPMC10511412 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature