The effect of high perioperative inspiratory oxygen fraction for abdominal surgery on surgical site infection: a systematic review and meta-analysis.

ABSTRACT: Guidelines from the World Health Organization strongly recommend the use of a high fraction of inspired oxygen (FiO₂) in adult patients undergoing general anesthesia to reduce surgical site infection (SSI). However, previous meta-analyses reported inconsistent results. We aimed to address this controversy by focusing specifically on abdominal surgery with relatively high risk of SSI. Medline, EMBASE, and Cochrane CENTRAL databases were searched. Randomized trials of abdominal surgery comparing high to low perioperative FiO₂ were included, given that the incidence of SSI was reported as an outcome. Meta-analyses of risk ratios (RR) were performed using a fixed effects model. Subgroup analysis and meta-regression were employed to explore sources of heterogeneity. We inc

SUBMITTER: Kuh JH 

PROVIDER: S-EPMC10511429 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature