Critical requirement of SOS1 for tumor development and microenvironment modulation in KRAS^G12D-driven lung adenocarcinoma.

ABSTRACT: The impact of genetic ablation of SOS1 or SOS2 is evaluated in a murine model of KRAS^G12D-driven lung adenocarcinoma (LUAD). SOS2 ablation shows some protection during early stages but only SOS1 ablation causes significant, specific long term increase of survival/lifespan of the KRAS^G12D mice associated to markedly reduced tumor burden and reduced populations of cancer-associated fibroblasts, macrophages and T-lymphocytes in the lung tumor microenvironment (TME). SOS1 ablation also causes specific shrinkage and regression of LUAD tumoral masses and components of the TME in pre-established KRAS^G12D LUAD tumors. The critical requirement of SOS1 for KRAS^G12D-driven LUAD is further confirmed by means of intravenous tail injection of KRAS^G12D

SUBMITTER: Baltanas FC 

PROVIDER: S-EPMC10511506 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature