Multiple neuron clusters on Micro-Electrode Arrays as an in vitro model of brain network.

ABSTRACT: Understanding the brain functioning is essential for governing brain processes with the aim of managing pathological network dysfunctions. Due to the morphological and biochemical complexity of the central nervous system, the development of general models with predictive power must start from in vitro brain network engineering. In the present work, we realized a micro-electrode array (MEA)-based in vitro brain network and studied its emerging dynamical properties. We obtained four-neuron-clusters (4N) assemblies by plating rat embryo cortical neurons on 60-electrode MEA with cross-shaped polymeric masks and compared the emerging dynamics with those of sister single networks (1N). Both 1N and 4N assemblies exhibited spontaneous electrical activity characterized by spiking and bursting signa

SUBMITTER: Brofiga M 

PROVIDER: S-EPMC10511538 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature