Epileptogenicity of white matter lesions in cerebral small vessel disease: a systematic review and meta-analysis.

ABSTRACT:

Background

The epileptogenic properties of white matter lesions (WML) in cerebral small vessel disease (CSVD) are not yet understood. The aim of our systematic review and meta-analysis was to estimate the association between the extent of WML in CSVD and epilepsy, analyze whether these WML are associated with an increased risk of seizure recurrence, and evaluate if treatment with anti-seizure medication (ASM) is justified in first-seizure patients with WML and no cortical lesions.

Methods

Following a pre-registered study protocol (PROSPERO-ID CRD42023390665), we systematically searched Pubmed and Embase for relevant literature comparing WML load between patients with epilepsy and controls as well as studies on seizure recurrence risk and ASM therapy in the presence vs. absen

SUBMITTER: Doerrfuss JI 

PROVIDER: S-EPMC10511556 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature