The rising role of cognitive reserve and associated compensatory brain networks in spinocerebellar ataxia type 2.

ABSTRACT: Pre-existing or enhanced cognitive abilities influence symptom onset and severity in neurodegenerative diseases, which improve an individual's ability to deal with neurodegeneration. This process is named cognitive reserve (CR), and it has acquired high visibility in the field of neurodegeneration. However, the investigation of CR has been neglected in the context of cerebellar neurodegenerative disorders. The present study assessed CR and its impact on cognitive abilities in spinocerebellar ataxia type 2 (SCA2), which is a rare cerebellar neurodegenerative disease. We investigated the existence of CR networks in terms of compensatory mechanisms and neural reserve driven by increased cerebello-cerebral functional connectivity. The CR of 12 SCA2 patients was assessed using the Cognitive Res

SUBMITTER: Siciliano L 

PROVIDER: S-EPMC10511586 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature