Quantifying whole bladder biomechanics using the novel pentaplanar reflected image macroscopy system.

ABSTRACT: Optimal bladder compliance is essential to urinary bladder storage and voiding functions. Calculated as the change in filling volume per change in pressure, bladder compliance is used clinically to characterize changes in bladder wall biomechanical properties that associate with lower urinary tract dysfunction. But because this method calculates compliance without regard to wall structure or wall volume, it gives little insight into the mechanical properties of the bladder wall during filling. Thus, we developed Pentaplanar Reflected Image Macroscopy (PRIM): a novel ex vivo imaging method to accurately calculate bladder wall stress and stretch in real time during bladder filling. The PRIM system simultaneously records intravesical pressure, infused volume, and an image of the bladder in fi

SUBMITTER: Hennig G 

PROVIDER: S-EPMC10511590 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature