Antiseizure medications for idiopathic generalized epilepsies: a systematic review and network meta-analysis.

ABSTRACT:

Objectives

To compare the efficacy and safety of antiseizure medications (ASMs), both as monotherapies and adjunctive therapies, for idiopathic generalized epilepsies (IGEs) and related entities.

Methods

Two reviewers independently searched PubMed, Embase, and the Cochrane Library for relevant randomized controlled trials from December 2022 to February 2023. Studies on the efficacy and safety of ASM monotherapies or adjunctive therapies for IGEs and related entities-including juvenile myoclonic epilepsy, childhood absence epilepsy (CAE), juvenile absence epilepsy, or generalized tonic-clonic seizures alone (GTCA)-were included. Efficacy outcomes were the proportions of patients remaining seizure free for 1, 3, 6, and 12 months; safety outcomes were the proportions of any tre

SUBMITTER: Chu H 

PROVIDER: S-EPMC10511599 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature