A typology of cerebral small vessel disease based on imaging markers.

ABSTRACT:

Background

Lacunes, microbleeds, enlarged perivascular spaces (EPVS), and white matter hyperintensities (WMH) are brain imaging features of cerebral small vessel disease (SVD). Based on these imaging markers, we aimed to identify subtypes of SVD and to evaluate the validity of these markers as part of clinical ratings and as biomarkers for stroke outcome.

Methods

In a cross-sectional study, we examined 1207 first-ever anterior circulation ischemic stroke patients (mean age 69.1 ± 15.4 years; mean NIHSS 5.3 ± 6.8). On acute stroke MRI, we assessed the numbers of lacunes and microbleeds and rated EPVS and deep and periventricular WMH. We used unsupervised learning to cluster patients based on these variables.

Results

We identified five clusters, of which the last three

SUBMITTER: Sperber C 

PROVIDER: S-EPMC10511610 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature