Deep learning segmentation results in precise delineation of the putamen in multiple system atrophy.

ABSTRACT:

Objectives

The precise segmentation of atrophic structures remains challenging in neurodegenerative diseases. We determined the performance of a Deep Neural Patchwork (DNP) in comparison to established segmentation algorithms regarding the ability to delineate the putamen in multiple system atrophy (MSA), Parkinson's disease (PD), and healthy controls.

Methods

We retrospectively included patients with MSA and PD as well as healthy controls. A DNP was trained on manual segmentations of the putamen as ground truth. For this, the cohort was randomly split into a training (N = 131) and test set (N = 120). The DNP's performance was compared with putaminal segmentations as derived by Automatic Anatomic Labelling, Freesurfer and Fastsurfer. For validation, we assessed the diagnosti

SUBMITTER: Rau A 

PROVIDER: S-EPMC10511621 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature