VE-cadherin in arachnoid and pia mater cells serves as a suitable landmark for in vivo imaging of CNS immune surveillance and inflammation.

ABSTRACT: Meninges cover the surface of the brain and spinal cord and contribute to protection and immune surveillance of the central nervous system (CNS). How the meningeal layers establish CNS compartments with different accessibility to immune cells and immune mediators is, however, not well understood. Here, using 2-photon imaging in female transgenic reporter mice, we describe VE-cadherin at intercellular junctions of arachnoid and pia mater cells that form the leptomeninges and border the subarachnoid space (SAS) filled with cerebrospinal fluid (CSF). VE-cadherin expression also marked a layer of Prox1⁺ cells located within the arachnoid beneath and separate from E-cadherin⁺ arachnoid barrier cells. In vivo imaging of the spinal cord and brain in female VE-cadherin-GFP re

SUBMITTER: Mapunda JA 

PROVIDER: S-EPMC10511632 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature