The Impact of Patient Age and Corticosteroids in Patients With Sulfonamide Hepatotoxicity.

ABSTRACT:

Introduction

Sulfonamides are widely used to treat and prevent various bacterial and opportunistic infections. The aim of this study was to describe the clinical presentation and outcomes of a large cohort of patients with sulfonamide hepatotoxicity.

Methods

Between 2004 and 2020, 105 patients with hepatotoxicity attributed to trimethoprim/sulfamethoxazole (TMP-SMZ) (n = 93) or other sulfonamides (n = 12) were enrolled. Available liver biopsies were reviewed by a single hepatopathologist.

Results

Among the 93 TMP-SMZ cases, 52% were female, 7.5% younger than 20 years, and the median time to drug-induced liver injury (DILI) onset was 22 days (range: 3-157). Younger patients were significantly more likely to have rash, fever, eosinophilia, and a hepatocellular injury pa

SUBMITTER: Fontana RJ 

PROVIDER: S-EPMC10511659 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature