NLRP3 selectively drives IL-1β secretion by Pseudomonas aeruginosa infected neutrophils and regulates corneal disease severity.
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ABSTRACT:
SUBMITTER: Minns MS
PROVIDER: S-EPMC10511713 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
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NLRP3 selectively drives IL-1β secretion by Pseudomonas aeruginosa infected neutrophils and regulates corneal disease severity.
Minns Martin S MS Liboro Karl K Lima Tatiane S TS Abbondante Serena S Miller Brandon A BA Marshall Michaela E ME Tran Chau Jolynn J Roistacher Alicia A Rietsch Arne A Dubyak George R GR Pearlman Eric E
Nature communications 20230920 1
Macrophages infected with Gram-negative bacteria expressing Type III secretion system (T3SS) activate the NLRC4 inflammasome, resulting in Gasdermin D (GSDMD)-dependent, but GSDME independent IL-1β secretion and pyroptosis. Here we examine inflammasome signaling in neutrophils infected with Pseudomonas aeruginosa strain PAO1 that expresses the T3SS effectors ExoS and ExoT. IL-1β secretion by neutrophils requires the T3SS needle and translocon proteins and GSDMD. In macrophages, PAO1 and mutants ...[more]
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