A role of inflammaging in aortic aneurysm: new insights from bioinformatics analysis.

ABSTRACT:

Introduction

Aortic aneurysms (AA) are prevalent worldwide with a notable absence of drug therapies. Thus, identifying potential drug targets is of utmost importance. AA often presents in the elderly, coupled with consistently raised serum inflammatory markers. Given that ageing and inflammation are pivotal processes linked to the evolution of AA, we have identified key genes involved in the inflammaging process of AA development through various bioinformatics methods, thereby providing potential molecular targets for further investigation.

Methods

The transcriptome data of AA was procured from the datasets GSE140947, GSE7084, and GSE47472, sourced from the NCBI GEO database, whilst gene data of ageing and inflammation were obtained from the GeneCards Database. To identify k

SUBMITTER: Wang S 

PROVIDER: S-EPMC10511768 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature