Contouring variation affects estimates of normal tissue complication probability for breast fibrosis after radiotherapy.

ABSTRACT:

Background

Normal tissue complication probability (NTCP) models can be useful to estimate the risk of fibrosis after breast-conserving surgery (BCS) and radiotherapy (RT) to the breast. However, they are subject to uncertainties. We present the impact of contouring variation on the prediction of fibrosis.

Materials and methods

280 breast cancer patients treated BCS-RT were included. Nine Clinical Target Volume (CTV) contours were created for each patient: i) CTV_crop (reference), cropped 5 mm from the skin and ii) CTV_skin, uncropped and including the skin, iii) segmenting the 95% isodose (Iso_95%) and iv) 3 different auto-contouring atlases generating uncropped and cropped contours (Atlas_skin/Atlas_crop). To illustrate the impact of contour variation on NTCP esti

SUBMITTER: Jaikuna T 

PROVIDER: S-EPMC10511799 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature