Natural mutations of human XDH promote the nitrite (NO₂^-)-reductase capacity of xanthine oxidoreductase: A novel mechanism to promote redox health?

ABSTRACT: Several rare genetic variations of human XDH have been shown to alter xanthine oxidoreductase (XOR) activity leading to impaired purine catabolism. However, XOR is a multi-functional enzyme that depending upon the environmental conditions also expresses oxidase activity leading to both O₂^·- and H₂O₂ and nitrite (NO₂^-) reductase activity leading to nitric oxide (·NO). Since these products express important, and often diametrically opposite, biological activity, consideration of the impact of XOR mutations in the context of each aspect of the biochemical activity of the enzyme is needed to determine the potential full impact of these variants. Herein, we show that known naturally occurring hXDH mutations do not have a uniform

SUBMITTER: Massimo G 

PROVIDER: S-EPMC10511815 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature