Exploration of potential novel drug targets and biomarkers for small cell lung cancer by plasma proteome screening.

ABSTRACT: Background: Small cell lung cancer (SCLC) is characterized by extreme invasiveness and lethality. There have been very few developments in its diagnosis and treatment over the past decades. It is urgently needed to explore potential novel biomarkers and drug targets for SCLC. Methods: Two-sample Mendelian Randomization (MR) was performed to investigate causal associations between SCLC and plasma proteins using genome-wide association studies (GWAS) summary statistics of SCLC from Transdisciplinary Research Into Cancer of the Lung Consortium (n_Case = 2,791 vs. n_Control = 20,580), and was validated in another cohort (n_Case = 2,664 vs. n_Control = 21,444). 734 plasma proteins and their genetic instruments of cis-acting protein quantitat

SUBMITTER: Wu Y 

PROVIDER: S-EPMC10511877 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature