A mechanism by which gut microbiota elevates permeability and inflammation in obese/diabetic mice and human gut.

ABSTRACT:

Objective

Ample evidence exists for the role of abnormal gut microbiota composition and increased gut permeability ('leaky gut') in chronic inflammation that commonly co-occurs in the gut in both obesity and diabetes, yet the detailed mechanisms involved in this process have remained elusive.

Design

In this study, we substantiate the causal role of the gut microbiota by use of faecal conditioned media along with faecal microbiota transplantation. Using untargeted and comprehensive approaches, we discovered the mechanism by which the obese microbiota instigates gut permeability, inflammation and abnormalities in glucose metabolism.

Results

We demonstrated that the reduced capacity of the microbiota from both obese mice and humans to metabolise ethanolamine results in e

SUBMITTER: Mishra SP 

PROVIDER: S-EPMC10512000 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature