Phenotypic and functional characteristics of murine CD11c+ B cells which is suppressed by metformin.

ABSTRACT: Since the description of age-associated or autoimmune-associated B cells (ABCs), there has been a growing interest in the role of these cells in autoimmunity. ABCs are differently defined depending on the research group and are heterogenous subsets. Here, we sought to characterize ABCs in Sle1/2/3 triple congenic (TC) mice, which is a well accepted mouse model of lupus. Compared to follicular (FO) B cells, ABCs have many distinct functional properties, including antigen presentation. They express key costimulatory molecules for T cell activation and a distinct profile of cytokines. Moreover, they exhibit an increased capacity for antigen uptake. ABCs were also compared with germinal center (GC) B cells, which are antigen activated B cell population. There are several phenotypic similaritie

SUBMITTER: Ramirez De Oleo I 

PROVIDER: S-EPMC10512061 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature