Feasibility of the preparation of cochleate suspensions from naturally derived phosphatidylserines.

ABSTRACT:

Introduction

Cochleates are cylindrical particles composed of dehydrated phospholipid bilayers. They are typically prepared by addition of calcium ions to vesicles composed of negatively charged phospholipids such as phosphatidylserines (PS). Due to their high physical and chemical stability, they provide an interesting alternative over other lipid-based drug formulations for example to improve oral bioavailability or to obtain a parenteral sustained-release formulation.

Methods

In the present study, the feasibility to prepare cochleate suspensions from soy lecithin-derived phosphatidylserines (SPS) was investigated and compared to the "gold standard" dioleoyl-phosphatidylserine (DOPS) cochleates. The SPS lipids covered a large range of purities between 53 and >96% and compu

SUBMITTER: Kristensen S 

PROVIDER: S-EPMC10512065 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature