Cytotoxic innate intraepithelial lymphocytes control early stages of Cryptosporidium infection.

ABSTRACT:

Background

Intraepithelial lymphocytes (IELs) are the first immune cells to contact and fight intestinal pathogens such as Cryptosporidium, a widespread parasite which infects the gut epithelium. IFN-γ producing CD4⁺ T IELs provide an efficient and a long-term protection against cryptosporidiosis while intraepithelial type 1 innate lymphoid cells limits pathogen spreading during early stages of infection in immunodeficient individuals. Yet, the role of T-cell like innate IELs, the most frequent subset of innate lymphocytes in the gut, remains unknown.

Methods

To better define functions of innate IELs in cryptosporidiosis, we developed a co-culture model with innate IELs isolated from Rag2^-/- mice and 3D intestinal organoids infected with <

SUBMITTER: Hariss F 

PROVIDER: S-EPMC10512070 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature