Complement factor D regulates collagen type I expression and fibroblast migration to enhance human tendon repair and healing outcomes.

ABSTRACT:

Introduction

Dense connective tissues (DCTs) such as tendon, ligament, and cartilage are important stabilizers and force transmitters in the musculoskeletal system. The healing processes after DCT injuries are highly variable, often leading to degenerative changes and poor clinical outcome. Biomarkers in relation to repair quality for human DCTs, especially tendon are lacking. This study expands our previous findings and aimed to characterize the mechanisms by which a potential biomarker of good outcomes, complement factor D (CFD), regulates tendon healing.

Methods

Quantitative mass spectrometry (QMS) profiling of tissue biopsies from the inflammatory phase of healing (n = 40 patients) and microdialysates from the proliferative phase of healing (n = 28 patients) were used to

SUBMITTER: Chen J 

PROVIDER: S-EPMC10512081 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature