Network-Based Spreading of Gray Matter Changes Across Different Stages of Psychosis.

ABSTRACT:

Importance

Psychotic illness is associated with anatomically distributed gray matter reductions that can worsen with illness progression, but the mechanisms underlying the specific spatial patterning of these changes is unknown.

Objective

To test the hypothesis that brain network architecture constrains cross-sectional and longitudinal gray matter alterations across different stages of psychotic illness and to identify whether certain brain regions act as putative epicenters from which volume loss spreads.

Design, settings, and participants

This case-control study included 534 individuals from 4 cohorts, spanning early and late stages of psychotic illness. Early-stage cohorts included patients with antipsychotic-naive first-episode psychosis (n = 59) and a group of pa

SUBMITTER: Chopra S 

PROVIDER: S-EPMC10512169 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature