Accelerated telomere shortening in adrenal zona reticularis in patients with prolonged critical illness.

ABSTRACT:

Background

The number of patients with prolonged critical illness (PCI) has been increasing in many countries, and the adrenal gland plays an important role in maintaining homeostasis during PCI. Chronic disease burden is reportedly associated with shorter telomere lengths in human tissues. Telomere shortening in human somatic cells is largely dependent on cell divisions, and critically short telomeres lead to cellular dysfunction and aging. However, the association between PCI and telomere lengths in human adrenal cells is poorly understood. In this study, we investigated this association to assess whether the burden of PCI could accelerate the aging process in adrenal cells.

Methods

Adrenocortical tissues from patients who died after PCI usually show a diffuse pattern of i

SUBMITTER: Nonaka K 

PROVIDER: S-EPMC10512174 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature