Computational modeling of ventricular-ventricular interactions suggest a role in clinical conditions involving heart failure.

ABSTRACT: Introduction: The left (LV) and right (RV) ventricles are linked biologically, hemodynamically, and mechanically, a phenomenon known as ventricular interdependence. While LV function has long been known to impact RV function, the reverse is increasingly being realized to have clinical importance. Investigating ventricular interdependence clinically is challenging given the invasive measurements required, including biventricular catheterization, and confounding factors such as comorbidities, volume status, and other aspects of subject variability. Methods: Computational modeling allows investigation of mechanical and hemodynamic interactions in the absence of these confounding factors. Here, we use a threesegment biventricular heart model and simple circulatory system to inves

SUBMITTER: Kim SM 

PROVIDER: S-EPMC10512181 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature