Genome mining as a biotechnological tool for the discovery of novel biosynthetic genes in lichens.

ABSTRACT: Natural products (NPs) and their derivatives are a major contributor to modern medicine. Historically, microorganisms such as bacteria and fungi have been instrumental in generating drugs and lead compounds because of the ease of culturing and genetically manipulating them. However, the ever-increasing demand for novel drugs highlights the need to bioprospect previously unexplored taxa for their biosynthetic potential. Next-generation sequencing technologies have expanded the range of organisms that can be explored for their biosynthetic content, as these technologies can provide a glimpse of an organism's entire biosynthetic landscape, without the need for cultivation. The entirety of biosynthetic genes can be compared to the genes of known function to identify the gene clusters potential

SUBMITTER: Singh G 

PROVIDER: S-EPMC10512267 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature