Examining Signatures of Natural Selection in Antifungal Resistance Genes Across Aspergillus Fungi.

ABSTRACT: Certain Aspergillus fungi cause aspergillosis, a set of diseases that typically affect immunocompromised individuals. Most cases of aspergillosis are caused by Aspergillus fumigatus, which infects millions of people annually. Some closely related so-called cryptic species, such as Aspergillus lentulus, can also cause aspergillosis, albeit at lower frequencies, and they are also clinically relevant. Few antifungal drugs are currently available for treating aspergillosis and there is increasing worldwide concern about the presence of antifungal drug resistance in Aspergillus species. Furthermore, isolates from both A. fumigatus and other Aspergillus pathogens exhibit substantial heterogeneity in their antifungal drug resistance profiles. To gain insi

SUBMITTER: Dos Santos RAC 

PROVIDER: S-EPMC10512362 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature