Causal association of polyunsaturated fatty acids with chronic pain: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Observational studies have indicated an association between polyunsaturated fatty acids (PUFAs) and chronic pain, but the potential causal link remains controversial. Here, we aimed to investigate whether a causal relationship exists between the concentration of circulating PUFAs and chronic pain as well as the direction of this association.

Methods

We collected statistical data from relevant genome-wide association studies to explore the causal link between four PUFAs, along with the ratio of omega-6 fatty acids (FAs) to omega-3 FAs (omega-6:3 ratio), and chronic pain in eight specific body parts. We used the inverse-variance weighting (IVW) method for two-sample Mendelian randomization (MR) analysis and conducted supplementary analyses using four other methods (

SUBMITTER: Dai Y 

PROVIDER: S-EPMC10512421 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature