Night-to-night variability in sleep and amyloid beta burden in normal aging.

ABSTRACT:

Introduction

Alzheimer's disease is associated with sleep disturbances and accumulation of cerebral amyloid beta. The objective was to examine whether actigraphy-detected sleep parameters might be biomarkers for early amyloid burden.

Methods

Participants underwent a week of actigraphy and an amyloid positron emission tomography (PET) scan. Sleep duration and continuity disruption (sleep fragmentation and nocturnal awakenings) were extracted and compared between amyloid-positive and amyloid-negative participants. Then multiple linear regressions were used between mean or night-to-night intra-individual variability (standard deviation) of sleep parameters and brain amyloid burden in a voxel-wise analysis.

Results

Eighty-six subjects were included (80.3 ± 5.4 years; 48.8

SUBMITTER: Jouvencel A 

PROVIDER: S-EPMC10512442 | biostudies-literature | 2023 Jul-Sep

REPOSITORIES: biostudies-literature